LOW SPINAL AND PELVIC BONE-MINERAL DENSITY AMONG INDIVIDUALS WITH DOWN-SYNDROME

The bone mineral density of 15 adults with Down syndrome was compared to 25 control subjects without Down syndrome. Bone mineral density was measured by dual x-ray absorptiometry with a Lunar DPX(TM) scanner. A rm, leg, pelvic, and spline bone mineral density was tested. Analysis of covariance was conducted for each variable; Down syndrome was the i ndependent variable, and the covariates were height, lean body mass, f at mass, age, and gender. No significant group differences were found for arm or leg bone mineral density. Individuals with Down syndrome ha d significantly lower pelvic and spinal bone mineral density. Before a djustment for covariates, percentage difference between group means fo r spine was 14.5% and for pelvis, 11.6%. Adjusted percentage was 11.1% and 13.9%, respectively. Suggestions for further research were made.