We present what we believe is the first report in the world literature
of penile necrosis due to mucormycosis, a rare and often fatal fungal
infection. This case of rhizopus mucormycosis began with a penile les
ion in a 27-year-old patient with undiagnosed diabetes; it led to necr
osis of the phallus, lower urinary tract, rectum, and pelvic musculatu
re and finally to death. Despite repeated aggressive surgical debridem
ent in conjunction with medical therapy, we were unable to halt the pr
ogression of the fungal and synergistic bacterial infections.