SYNTHESIS AND ANTITUMOR-ACTIVITY SPIN-LABELED DERIVATIVES OF PODOPHYLLOTOXIN

Authors
TIAN X WANG YG YANG MG CHEN YZ
Citation
X. Tian et al., SYNTHESIS AND ANTITUMOR-ACTIVITY SPIN-LABELED DERIVATIVES OF PODOPHYLLOTOXIN, Life sciences, 60(8), 1997, pp. 511-517
Citations number
21
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
60
Issue
8
Year of publication
1997
Pages
511 - 517
Database
ISI
SICI code
0024-3205(1997)60:8<511:SAASDO>2.0.ZU;2-1
Abstract
Three new nitroxyl labeled derivatives of podophyllotoxin (4) under ba r-(6) under bar have been synthesized and evaluated for their antitumo r activity in vitro. Compounds (4) under bar-(6) under bar showed sign ificant inhibitory activity against human nasopharyngeal carcinoma KB, lung cancer A549 and stomach carcinoma SGC-7901 cells, as well as mous e leukemia L1210 and P388 cells. Compounds (4) under bar and (5) under bar exhibited comparable or superior activity to clinically used etop oside (VP-16,(2) under bar) in their inhibition of these cell lines.