NOCICEPTIN - AN ENDOGENOUS AGONIST FOR CENTRAL OPIOID LIKE(1) (ORL(1)) RECEPTORS POSSESSES SYSTEMIC VASORELAXANT PROPERTIES

Authors
GUMUSEL B HAO QZ HYMAN A CHANG JK KAPUSTA DR LIPPTON H
Citation
B. Gumusel et al., NOCICEPTIN - AN ENDOGENOUS AGONIST FOR CENTRAL OPIOID LIKE(1) (ORL(1)) RECEPTORS POSSESSES SYSTEMIC VASORELAXANT PROPERTIES, Life sciences, 60(8), 1997, pp. 141-145
Citations number
9
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
60
Issue
8
Year of publication
1997
Pages
141 - 145
Database
ISI
SICI code
0024-3205(1997)60:8<141:N-AEAF>2.0.ZU;2-W
Abstract
The purpose of the present study was to investigate the effects of noc iceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were pre contracted with phenylephrine (100 nanomolar), nociceptin (3x10(-11) - 3x10(-6) M) decreased tension in a concentration-dependent manner. Th e present data suggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressur e and regional blood flow.