T-LYMPHOCYTE RECEPTOR DEFICIENCIES

Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 componen ts have lead to dramatic, yet dissimilar, effects on T-cell developmen t and to selective deficits in peripheral T-cell subsets. Recent studi es of human patients and animal models with CD3 deficiencies are provi ding insights into the redundant and unique roles of these molecules.