4 NEW CASES OF INVERTED TERMINAL DUPLICATION - A MODIFIED HYPOTHESIS OF MECHANISM OF ORIGIN

We present 4 recently diagnosed cases of inverted tandem duplication w ith involvement of the respective terminal band, Based on these 4 case s and review of the literature, the term ''inverted terminal duplicati on'' is proposed to designate specifically the type of inverted tandem duplication which involves the terminal band, A modification of the p revious hypothesis of mechanism of origin is advanced, It is speculate d further that a telomeric deletion of a meiotic chromosome followed b y a U-type reunion of the chromatids, considered to be the first steps of the proposed mechanism of origin, may not be a rare gonadal event. (C) 1995 Wiley-Liss, Inc.