ANTIPYRINE, COUMARIN AND GLIPIZIDE AFFECT N-ACETYLATION MEASURED BY CAFFEINE TEST

Citation
I. Klebovich et al., ANTIPYRINE, COUMARIN AND GLIPIZIDE AFFECT N-ACETYLATION MEASURED BY CAFFEINE TEST, Biomedicine & pharmacotherapy, 49(5), 1995, pp. 225-227
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
ISSN journal
07533322
Volume
49
Issue
5
Year of publication
1995
Pages
225 - 227
Database
ISI
SICI code
0753-3322(1995)49:5<225:ACAGAN>2.0.ZU;2-W
Abstract
The effect of various treatments on acetylation status measured by caf feine metabolites was investigated in 17 subjects with non-insulin dep endent diabetes mellitus (NIDDM). The test drugs, caffeine (200 mg), a ntipyrine (20 mg/kg) and coumarin (5 mg), were given simultaneously, a nd urinary ino-6-formyl-amino-3-methyluracil/1-methylxanthine (AFMU/1X ) molar ratio was measured before and after 8 weeks of therapy. The ur inary AFMU/1X molar ratio decreased(p< 0.05) after 8 weeks of therapy with glipizide (2.5 mg), but remained unaltered in those treated with placebo or those who self-monitored blood glucose (SMBG) by glucometer . Antipyrine and coumarin decreased (p < 0.05) the AFMU/1X molar ratio both in diabetics and healthy volunteers. Our data demonstrate that g lipizide, antipyrine and coumarin may interfere with the classificatio n of acetylator status measured by caffeine metabolites.