CHIRAL SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE ENANTIOMERS OFSM(32), A NEW ANALGESIC AND COGNITION-ENHANCING AGENT

Authors
ROMANELLI MN BARTOLINI A BERTUCCI C DEI S GHELARDINI C GIOVANNINI MG GUALTIERI F PEPEU G SCAPECCHI S TEODORI E
Citation
Mn. Romanelli et al., CHIRAL SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE ENANTIOMERS OFSM(32), A NEW ANALGESIC AND COGNITION-ENHANCING AGENT, Chirality, 8(8), 1996, pp. 579-584
Citations number
16
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
8
Issue
8
Year of publication
1996
Pages
579 - 584
Database
ISI
SICI code
0899-0042(1996)8:8<579:CSAPEO>2.0.ZU;2-K
Abstract
The enantiomers of 3-alpha-tropyl 2-(phenylthio)butyrate (SM(32), 1) w ere prepared by chiral synthesis and tested for analgesic, cognition-e nhancing and ACh-releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R-()-hyoscyamine. (C) 1997 Wiley-Liss, Inc.