THE MAJOR ACUTE-PHASE SERUM-PROTEIN IN PIGS IS HOMOLOGOUS TO HUMAN PLASMA KALLIKREIN SENSITIVE PK-120

Authors
GONZALEZRAMON N ALAVA MA SARSA JA PINEIRO M ESCARTIN A GARCIAGIL A LAMPREAVE F PINEIRO A
Citation
N. Gonzalezramon et al., THE MAJOR ACUTE-PHASE SERUM-PROTEIN IN PIGS IS HOMOLOGOUS TO HUMAN PLASMA KALLIKREIN SENSITIVE PK-120, FEBS letters, 371(3), 1995, pp. 227-230
Citations number
22
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
371
Issue
3
Year of publication
1995
Pages
227 - 230
Database
ISI
SICI code
0014-5793(1995)371:3<227:TMASIP>2.0.ZU;2-H
Abstract
A major acute phase protein (pig-MAP) has been isolated from the sera of pigs after turpentine injection, The protein is the pig counterpart of a recently cloned human serum protein denominated PK-120, which is a putative substrate for kallikrein [Nishimura ct al., 1995 FEES Lett , 357, 207-211], The protein exists in other mammalian species and it is also an acute phase protein, at least in the rat, Pig-MAP shows hom ology, as PK-120, with the heavy chain 2 (HC-2) of the inter-alpha-try psin inhibitor superfamily but does not possess trypsin inhibitory act ivity.