PHOTODYNAMIC THERAPY OF EXPERIMENTAL-TUMORS WITH ZN(II)-PHTHALOCYANINE AND PULSED-LASER IRRADIATION

Authors
SHOPOVA M STOICHKOV N MILEV A PEEV M GEORGIEV K GIZBREHT A JORI G RICCHELLI F
Citation
M. Shopova et al., PHOTODYNAMIC THERAPY OF EXPERIMENTAL-TUMORS WITH ZN(II)-PHTHALOCYANINE AND PULSED-LASER IRRADIATION, Lasers in medical science, 10(1), 1995, pp. 43-46
Citations number
16
Categorie Soggetti
Medical Laboratory Technology
Journal title
Lasers in medical science → ACNP
ISSN journal
02688921
Volume
10
Issue
1
Year of publication
1995
Pages
43 - 46
Database
ISI
SICI code
0268-8921(1995)10:1<43:PTOEWZ>2.0.ZU;2-O
Abstract
The effectiveness of a pulsed dye laser (673 nm) for photodynamic ther apy (PDT) of tumours in the presence of Zn(II)-phthalocyanine (ZnPc) w as evaluated using Lewis lung carcinoma-bearing mice. The tumours were irradiated with different pulse energies (from 0.4 to 10 mJ) at a con stant fluence of 0.6 J cm(-2) at 24 h after administration of 0.25 mg kg(-1) body weight liposome-incorporated ZnPc. Maximal PDT effect, as evaluated by changes in mean tumour diameter, animal survival time and histological evaluation of tumour necrosis, was observed after 3.0 mJ pulse energy irradiation which appears to yield a deeper light penetr ation and a more efficient sensitizer excitation when compared with lo wer or higher pulse energies. Electron microscopic analysis of photo-t reated tumour indicates preferential damage to malignant tissue as com pared to endothelial cells.