THE EFFECT OF THE ANTISPERM AUTO-ANTIBODY-BOUND SPERM ON IN-VITRO FERTILIZATION OUTCOME

To evaluate the effects of antisperm auto-antibody-bound sperm on the outcome of in vitro fertilization-embryo transfer (IVF-ET), 160 infert ile couples undergoing treatment by in vitro fertilization were recrui ted in this study. In the study group (11 couples, 15 cycles), the mal e partners were positive for antisperm autoantibodies determined by im munobead test (IBT). In the control group (149 couples, 152 cycles), t he men had no such antibodies. The percentages of fertilization rate, cleavage rate and pregnancy rate of the study group and control group were 75.0+/-5.2% vs. 69.3+/-2.4%; 82.8+/-3.7% vs. 89.8+/-1.2% and 6.7% vs. 11.8%, respectively. There were no significant differences in in vitro fertilization outcome between both groups. The region, type and/ or percentage of sperm-bound antibodies also had no effect on the in,v itro fertilization outcome. In conclusion, in vitro fertilization-embr yo transfer is not significantly affected by antisperm autoantibody-ho und sperm determined by immunobead test.