A previously unreported syndrome of congenital craniofacial and anorec
tal anomalies affecting a woman and her two daughters is described. Fe
atures include bilateral cleft lip, cleft palate, bilateral upper and
lower lid lag, and imperforate anus. The findings are consistent with
an autosomal dominant pattern of inheritance. There were no identifiab
le intrauterine fetal insults. A detailed description of these anomali
es, the subsequent surgical corrections, and a discussion of previousl
y unreported syndromes with isolated features are the subject of this
report.