THE EPIDEMIOLOGY OF COMMUNITY-ACQUIRED PNEUMONIA AMONG HOSPITALIZED ADULTS

Objective: To identify and characterize the aethological agents of com munity-acquired pneumonia (CAP) among hospitalized patients, as an aid in therapeutic decision-making. Method: A prospective 1 year study of all patients hospitalized with CAP in the Negev region of Israel. The aetiology was determined by blood and pleural fluid cultures, and spe cific serological testing for pathogenic agents. Eighty-nine percent o f the patients underwent follow-up for a month after discharge. Result s: The study included 346 patients (53% males, mean age 49.3+/-19.5, r ange 17-94). A single aetiologic agent was identified in 146 patients (42.2%), multiple agents were found in 133 (38.4%), and no agent was i dentified in 67 (19.4%). Among the common pathogens were Pneumococcus sp. in 148 patients (42.8%), Mycoplasma pneumoniae (101, 29.2%), Chlam ydia pneumoniae (62, 17.9%), Legionella sp. (56, 16.2%), viruses (35, 10.1%), Coxiella burnetii (20, 5.8%), Haemophilus influence (19, 5.5%) , and other bacteria (21, 6.1%). Approximately 70% of the patients inf ected with M. pneumoniae and C. burnetti were younger than 45 years (P <0.05). In contrast, about 50% of the patients with C. pneumoniae (TWA R) were over the age of 65 (P=0.03). The presence of comorbidity was a ssociated with a greater frequency of bacterial aetiologies (57% vs. 4 4%, P=0.02), and fewer infections with M. pneumoniae (15% vs. 36%, P=0 .0004), or C. burnetii (2% vs. 8%, P=0.02). Specific causative agents were associated with specific seasons: viruses between December and Ap ril (P=0.03), and Legionella sp. from July to October (P=0.003). In co ntrast, no seasonal variation was associated with pneumococcus, M. pne umoniae, or C. pneumoniae (TWAR). Conclusions: Patients are hospitaliz ed with CAP throughout the year. Since the pathogen is usually unknown at hospitalization, epidemiological data is important for choosing me dication. The findings of this study point to the importance of macrol ides alone or in combination with cephalosporins, as the treatment of choice for patients in our region.