CLONAL EXPANSION OF SUPERANTIGEN-REACTIVE T-CELLS IS RESISTANT TO FK506 IN MICE WITH AIDS

Authors
YOSHIKAI Y KIDOKORO H KIMURA K AOKI Y MAKINO M HIROMATSU K
Citation
Y. Yoshikai et al., CLONAL EXPANSION OF SUPERANTIGEN-REACTIVE T-CELLS IS RESISTANT TO FK506 IN MICE WITH AIDS, Journal of virology, 71(1), 1997, pp. 746-749
Citations number
22
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
71
Issue
1
Year of publication
1997
Pages
746 - 749
Database
ISI
SICI code
0022-538X(1997)71:1<746:CEOSTI>2.0.ZU;2-1
Abstract
Subcutaneous injection of FK506 (10 mg/kg of body weight) completely b locked the clonal expansion of staphylococcal enterotoxin A (SEA)-reac tive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilizat ion of a FK506-insensitive pathway for clonal expansion of superantige n-reactive T cells.