Objective The authors determined the role of Nd:YAG laser reduction pn
eumonoplasty for selected patients with diffuse emphysema. Summary Bac
kground Data The study is based on the concepts introduced 30 years ag
o by Brantigan regarding the value of lung reduction surgery in patien
ts with emphysema. The authors used minimally invasive techniques with
the hopes of providing appropriate clinical results with the least su
rgical morbidity. Methods Fifty-five patients with advanced symptomati
c emphysema were treated with unilateral Nd:YAG laser reduction pneumo
noplasty to achieve lung volume reduction. Results Patients experience
d significant improvement in exercise capacity and relief of breathles
sness. This correlated with improvement in objective measures of pulmo
nary function and with reduction in lung volume by radiographic and sp
irometric measures. Significant associated hospital morbidity and a 5.
5% mortality were associated. Conclusions These encouraging results wi
th treatment of only one lung will be built on with both sequential lu
ng and simultaneous, bilateral lung treatment protocols.