PHARMACOKINETICS OF CEFODIZIME FOLLOWING SINGLE DOSES OF 0.5, 1.0, 2.0, AND 3.0 GRAMS ADMINISTERED INTRAVENOUSLY TO HEALTHY-VOLUNTEERS

Cefodizime is a new expanded-spectrum cephalosporin for parenteral use which possesses a broad antibacterial spectrum and potent antibacteri al activity and is stable against most beta-lactamases. The aim of thi s study was to assess the pharmacokinetics of cefodizime, administered intravenously, over the dose range of 0.5 to 3.0 g in healthy volunte ers, Concentrations of cefodizime in the serum and urine were determin ed by high-performance liquid chromatography. The area under the conce ntration-time curve from 0 h to infinity and the amount of drug excret ed in urine from 0 to 34 h increased in a linear, desk-dependent manne r with increasing doses of antibiotic from 6.5 to 3.0 g. Mean concentr ations of cefodizime in plasma at the end of infusion increased from 9 7 to 440 mg liter(-1) over the dose range 0.5 to 3.0 g and displayed a slight deviation from linearity at doses in excess of 2.0 g. Total pl asma clearance (3.11 liters h(-1)), volume of distribution at steady s tate (10.5 liters), terminal elimination half-life (3.3 h), and renal clearance (1.91 liters h(-1)) remained constant over the doses adminis tered, Cefodizime was well tolerated in this study.