IN-VITRO ACTIVITY OF LEVOFLOXACIN, SINGLY AND IN COMBINATION WITH RIFAMYCIN ANALOGS, AGAINST MYCOBACTERIUM-LEPRAE

Authors
DHOPLE AM IBANEZ MA
Citation
Am. Dhople et Ma. Ibanez, IN-VITRO ACTIVITY OF LEVOFLOXACIN, SINGLY AND IN COMBINATION WITH RIFAMYCIN ANALOGS, AGAINST MYCOBACTERIUM-LEPRAE, Antimicrobial agents and chemotherapy, 39(9), 1995, pp. 2116-2119
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
9
Year of publication
1995
Pages
2116 - 2119
Database
ISI
SICI code
0066-4804(1995)39:9<2116:IAOLSA>2.0.ZU;2-M
Abstract
The in vitro susceptibility of Mycobacterium leprae to levofloxacin wa s studied by using two biochemical parameters to measure the metabolic activity of the organism, Levofloxacin consistently exhibited twofold greater bactericidal activity than ofloxacin, with the MIC being 0.75 mu g/ml. When combined with one of the three rifamycin analogs, syner gism was obtained with KRM-1648 and rifabutin but not with rifampin.