EVALUATION OF HIGH-DOSE REGIMEN OF PAROMOMYCIN AGAINST CRYPTOSPORIDIOSIS IN THE DEXAMETHASONE-TREATED RAT MODEL

Authors
VERDON R POLIANSKI J GAUDEBOUT C MARCHE C GARRY L CARBON C POCIDALO JJ
Citation
R. Verdon et al., EVALUATION OF HIGH-DOSE REGIMEN OF PAROMOMYCIN AGAINST CRYPTOSPORIDIOSIS IN THE DEXAMETHASONE-TREATED RAT MODEL, Antimicrobial agents and chemotherapy, 39(9), 1995, pp. 2155-2157
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
9
Year of publication
1995
Pages
2155 - 2157
Database
ISI
SICI code
0066-4804(1995)39:9<2155:EOHROP>2.0.ZU;2-W
Abstract
In the dexamethasone-treated rat model of cryptosporidiosis, paromomyc in was effective at a dosage of 50 mg/kg/day or more for ileal infecti on and 200 mg/kg/day or more for cecal infection. At 1 and 3 weeks aft er treatment, a persistent infection was demonstrated in all rats. The se results confirm the anticryptosporidial activity of paromomycin and underscore the limitations of this compound because of its potential toxicity at such high dosages and its inability to eradicate the infec tion.