INFLUENCE OF DEXAMETHASONE ON EFFICACY OF CEFTRIAXONE AND VANCOMYCIN THERAPY IN EXPERIMENTAL PNEUMOCOCCAL MENINGITIS

Citation
C. Cabellos et al., INFLUENCE OF DEXAMETHASONE ON EFFICACY OF CEFTRIAXONE AND VANCOMYCIN THERAPY IN EXPERIMENTAL PNEUMOCOCCAL MENINGITIS, Antimicrobial agents and chemotherapy, 39(9), 1995, pp. 2158-2160
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
ISSN journal
00664804
Volume
39
Issue
9
Year of publication
1995
Pages
2158 - 2160
Database
ISI
SICI code
0066-4804(1995)39:9<2158:IODOEO>2.0.ZU;2-E
Abstract
Using a rabbit model of meningitis, we sought to determine whether con comitant use of dexamethasone affects the penetration and efficacy of ceftriaxone or vancomycin in cerebrospinal fluid. Rabbits were inocula ted with a penicillin-sensitive strain of Streptococcus pneumoniae and treated with ceftriaxone or vancomycin with or without dexamethasone. In the ceftriaxone-treated groups, no statistically significant diffe rences were seen between the group treated with dexamethasone and that without dexamethasone; however, in the vancomycin-treated groups we f ound statistically significant lower cerebrospinal fluid vancomycin le vels at 2 h in the dexamethasone-treated rabbits and differences in ba cterial killing.