CHANGES IN INDEXES OF LIPOPROTEINS ATHERO GENEITY INDUCED BY EXOGENOUS INFLUENCES IN PATIENTS WITH DIFFERENT APOPROTEIN-E PHENOTYPES

Relationship of genetically determined apoprotein E polymorphism to th e type of plasma lipoprotein system response to influences which modif y levels of dietory (exogenous) or synthesized in the liver (endogenou s) lipoproteins was studied. Changes in lipoprotein system after each meal were more favorable in E3/2 phenotype than in E3/3 or E4/3. Corre ction of moderate hyperlipidemia in phenotype E3/2 by sustained releas e nicotinic acid was followed by the least pronounced changes of param eters of lipoprotein spectrum in response to meals. One should take th is into consideration when selecting type of hypolipidemic therapy.