THE 3'-UNTRANSLATED REGIONS FROM THE TRYPANOSOMA-BRUCEI PHOSPHOGLYCERATE KINASE-ENCODING GENES MEDIATE DEVELOPMENTAL REGULATION

Authors
BLATTNER J CLAYTON CE
Citation
J. Blattner et Ce. Clayton, THE 3'-UNTRANSLATED REGIONS FROM THE TRYPANOSOMA-BRUCEI PHOSPHOGLYCERATE KINASE-ENCODING GENES MEDIATE DEVELOPMENTAL REGULATION, Gene, 162(1), 1995, pp. 153-156
Citations number
28
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
162
Issue
1
Year of publication
1995
Pages
153 - 156
Database
ISI
SICI code
0378-1119(1995)162:1<153:T3RFTT>2.0.ZU;2-P
Abstract
The phosphoglycerate kinase (PGK)-encoding genes of Trypanosoma brucei are transcribed in a polycistronic fashion, but the mRNAs encoding th e three PGK isozymes show differing developmental regulation. We demon strate here that the 3'-untranslated regions of the major cytoplasmic and glycosomal PGK isozymes are capable of conferring the anticipated types of regulation on a transfected reporter gene.