GROWTH-FACTORS IN SKIN WOUND-HEALING

The healing of skin involves a wide range of cellular, molecular, phys iological and biochemical events. During the healing process, cells mi grate to wound sites where they proliferate and synthesize extracellul ar matrix components in order to reconstitute a tissue closely similar to the original one. This activity is regulated by mediators secreted from the wound border cells such as PDGE EGF, TGF beta and many other cytokines. Their effects on cells has been demonstrated in vivo and i n vitro. The aim of this article is to summarize tile sequential event s that occur during wound healing notably cell migration, proliferatio n and phenotypic differentiation and to describe the cellular interact ions involving growth factors at the molecular level.