ASYMMETRIC-SYNTHESIS OF DIDEAZAFOLATE ANTITUMOR AGENTS VIA AMIDOMETHYLATION OF NONRACEMIC OXAZOLIDINONE IMIDATES - SYNTHESIS OF LY309887, ACYTOTOXIC DIDEAZAFOLATE ANALOG RELATED TO LOMETREXOL

Authors
BARNETT CJ WILSON TM EVANS DA SOMERS TC
Citation
Cj. Barnett et al., ASYMMETRIC-SYNTHESIS OF DIDEAZAFOLATE ANTITUMOR AGENTS VIA AMIDOMETHYLATION OF NONRACEMIC OXAZOLIDINONE IMIDATES - SYNTHESIS OF LY309887, ACYTOTOXIC DIDEAZAFOLATE ANALOG RELATED TO LOMETREXOL, Tetrahedron letters, 38(5), 1997, pp. 735-738
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
5
Year of publication
1997
Pages
735 - 738
Database
ISI
SICI code
0040-4039(1997)38:5<735:AODAAV>2.0.ZU;2-Z
Abstract
The asymmetric synthesis of LY309887, a cytotoxic dideazatetrahydrofol ate analog related to lometrexol, has been accomplished via an applica tion of diastereoselective amidomethylation of a chiral titanium (TV) acyloxazolidinone enolate. (C) 1997, Elsevier Science Ltd.