ACYLATION OF ALPHA-AMINOALKYL-COPPER AND CUPRATE REAGENTS WITH ACID-CHLORIDES - IMPROVED YIELDS WITH SOLUBLE COPPER(I) SALTS

Authors
DIETER RK SHARMA RR RYAN W
Citation
Rk. Dieter et al., ACYLATION OF ALPHA-AMINOALKYL-COPPER AND CUPRATE REAGENTS WITH ACID-CHLORIDES - IMPROVED YIELDS WITH SOLUBLE COPPER(I) SALTS, Tetrahedron letters, 38(5), 1997, pp. 783-786
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
5
Year of publication
1997
Pages
783 - 786
Database
ISI
SICI code
0040-4039(1997)38:5<783:AOAACR>2.0.ZU;2-Z
Abstract
alpha-Aminoalkylcopper reagents prepared from soluble CuX . 2LiCl give modest to good yields of alpha-aminoketones upon reaction with acid c hlorides. Higher yields are generally obtained with CuCl . 2LiCl than with CuCN . 2LiCl. Improved yields can be obtained by utilization of c uprate reagents prepared from CuCN . 2LiCl and 2.0 equivalents of alph a-lithiocarbamates. (C) 1997, Elsevier Science Ltd.