STRUCTURES OF BACTERIAL IMMUNOGLOBULIN-BINDING DOMAINS AND THEIR COMPLEXES WITH IMMUNOGLOBULINS

Three-dimensional structures are now available for several immunoglobu lin binding domains from bacterial proteins A, G, and L. X-ray diffrac tion and NMR experiments on complexes of these domains with portions o f immunoglobulins have revealed common structural themes used in these interactions. These data expand our understanding of structure/functi on relationships in these molecular recognition processes and provide the basis for rational design of artificial immunoglobulin-binding mol ecules.