AN ATLAS OF RENOGRAPHY WITH TC-99M SESTAMIBI - COMPARISON WITH TC-99MDTPA

Tc-99m sestamibl demonstrates considerable renal uptake followed by ne t urinary clearance similar to that of creatinine. The authors have pr eviously shown that renograms could be obtained in cardiac patients by imaging during the rest injection of the perfusion agent. The present study shows correlating Tc-99m sestamibi and Tc-99m DTPA studies in h ypertensive patients with a spectrum of findings, including aortic ane urysms, asymmetry due to renovascular disease, cysts, bilateral renal dysfunction, and horseshoe kidney, Tc-99m sestamibi images have persis ting background activity in the liver and spleen, but show renal struc ture and function in adequate detail. Quantitative analysis confirms t hat Tc-99m sestamibi has higher renal uptake, but less excretion than Tc-99m DTPA. Review of these correlating studies suggests straightforw ard transfer of diagnostic expertise with standard renography to this new application.