Jw. Tapsall et al., HIGH-LEVEL QUINOLONE RESISTANCE IN NEISSERIA-GONORRHOEAE - A REPORT OF 2 CASES, Sexually transmitted diseases, 22(5), 1995, pp. 310-311
Background and Objectives: Fluoroquinolones are widely used oral agent
s for treating Neisseria gonorrhoeae. Resistance to these agents is sp
oradic and usually at a low level. Two instances of high-dose ciproflo
xacin regimens failing in the treatment of gonococcal infection, cause
d by strains with high-level quinolone resistance, are reported. Study
Design: This is a case report. Conclusion: High-level resistance to q
uinolone antibiotics resulting in treatment failure was observed in tw
o distinct gonococcal isolates from patients infected in the Philippin
es (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continu
ed monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is
appropriate and prudent.