HIGH-LEVEL QUINOLONE RESISTANCE IN NEISSERIA-GONORRHOEAE - A REPORT OF 2 CASES

Background and Objectives: Fluoroquinolones are widely used oral agent s for treating Neisseria gonorrhoeae. Resistance to these agents is sp oradic and usually at a low level. Two instances of high-dose ciproflo xacin regimens failing in the treatment of gonococcal infection, cause d by strains with high-level quinolone resistance, are reported. Study Design: This is a case report. Conclusion: High-level resistance to q uinolone antibiotics resulting in treatment failure was observed in tw o distinct gonococcal isolates from patients infected in the Philippin es (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continu ed monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is appropriate and prudent.