VALIDATED CAPILLARY ELECTROPHORESIS METHOD FOR THE ASSAY OF A RANGE OF BASIC DRUGS

Authors
ALTRIA KD FRAKE P GILL I HADGETT T KELLY MA RUDD DR
Citation
Kd. Altria et al., VALIDATED CAPILLARY ELECTROPHORESIS METHOD FOR THE ASSAY OF A RANGE OF BASIC DRUGS, Journal of pharmaceutical and biomedical analysis, 13(8), 1995, pp. 951-957
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
13
Issue
8
Year of publication
1995
Pages
951 - 957
Database
ISI
SICI code
0731-7085(1995)13:8<951:VCEMFT>2.0.ZU;2-I
Abstract
A capillary electrophoresis method has been developed and validated fo r the analysis of a wide range of basic drugs. Acceptable precision wa s obtained by employing an internal standard. Optimal sensitivity was obtained using low UV wavelengths. An experimentally designed study sh owed the method to be robust. The method has advantages over HPLC in t erms of simplicity, speed and cost. The method is now in routine use f or identity confirmation and assay of both drug substance and formulat ions.