Acute compartment syndrome (ACS) is caused by conditions that either d
ecrease the size of the compartment or increase the content of the com
partment. Intracompartmental pressures are raised, thereby initiating
a sequence of events that results in myoneural injury. Although limb t
rauma is the most common and well-recognized etiology of ACS, the caus
e is frequently not readily apparent, Thyroid disease is not a commonl
y recognized cause of ACS; only one case of ACS associated with hypoth
yroidism has been previously reported. We now describe a second case o
f ACS in a patient with severe hypothyroidism and discuss the possible
pathogenesis of this association.