Te. Helton et Ja. Magner, BETA-GALACTOSIDE ALPHA-2,3-SIALYLTRANSFERASE MESSENGER-RNA INCREASES IN THYROTROPHS OF HYPOTHYROID MICE, Thyroid, 5(4), 1995, pp. 315-317
Our goal was to learn about the cellular mechanism(s) responsible for
the increased sialylation of thyroid-stimulating hormone (TSH) during
hypothyroidism, We used irt situ hybridization to examine the beta-gal
actoside alpha-2,3-sialyltransferase mRNA content in thyrotrophs and c
orticotrophs of euthyroid and hypothyroid [propylthiouracil (PTU)-trea
ted] mice, The alpha-2,3-sialyltransferase mRNA level was 66, 70, 296,
and 223% higher in hypothyroid thyrotrophs than in euthyroid thyrotro
phs after mice received PTU for 1, 2, 3, and 6 weeks, respectively, In
creased transcription of this gene, or mRNA stabilization, may partial
ly explain the increased sialylation of TSH during hypothyroidism.