PATHOGENESIS OF TOURETTES-SYNDROME

This review presents a model of disease pathogenesis in the context of CNS development. It begins with an exploration of the clinical featur es and natural history of Tourette's syndrome. This is followed by a c onsideration of the role of genetic and nongenetic factors. An effort is then made to review the anatomical organization of the basal gangli a and related cortical sites. These circuits are intimately involved i n the normal processing of sensorimotor, cognitive, and emotionally la den information. Evidence implicating these circuits in the pathobiolo gy of Tourette's syndrome is then considered. The review closes with t he prospects for advances in interdisciplinary research and therapeuti cs using this model as a guide.