AT LEAST 9 CASES OF TRISOMY 11Q23-]QTER IN ONE GENERATION AS A RESULTOF FAMILIAL T(11-13) TRANSLOCATION

Carriers of balanced reciprocal translocations may have a (high) risk for producing liveborn children with an unbalanced karyotype. We repor t a large family in which a translocation between the long arm of chro mosome 11 and the short arm of chromosome 13 is segregating in at leas t five generations, During the course of our study 15 carriers of the balanced translocation were identified and nine cases of partial triso my of the long arm of chromosome 11 were defected during pre- and post natal studies. Several of the patients were thoroughly clinically exam ined and compared with similar published cases.