T. Ozben et al., PLASMA AND URINE MALONDIALDEHYDE LEVELS IN NON-INSULIN-DEPENDENT DIABETIC-PATIENTS WITH AND WITHOUT MICROALBUMINURIA, International journal of clinical & laboratory research, 25(3), 1995, pp. 162-164
Malondialdehyde, a marker of lipid peroxidation, was measured as thiob
arbituric acid-reactive substance in 78 non-insulin-dependent diabetic
patients and 28 healthy subjects. Patients were divided into groups a
nd subgroups according to the presence of microalbuminuria and other c
omplications. Plasma and urine malondialdehyde concentrations were sig
nificantly higher in patients with and without microalbuminuria than i
n controls. In contrast to urine malondialdehyde, plasma malondialdehy
de levels were significantly higher in microalbuminuric diabetes than
in the normoalbuminuric diabetic group. There was no correlation betwe
en malondialdehyde concentration and glycemic control. This study conf
irmed the existence of lipid peroxidation disorders in diabetic patien
ts.