STUDIES ON THE STEREOSELECTIVE AND ENANTIOSELECTIVE SYNTHESIS OF 11,12-EPOXYSARCOPHYTOL-A, 11,12-EPOXYSARCOPHYTOL-A-ACETATE AND 11,12-EPOXYCEMBRENE-C - SYNTHESIS OF OXY-14-BROMO-2(Z),4(E),8(E)-TETRADECATRIENENITRILE

Authors
YUE XJ LI YL
Citation
Xj. Yue et Yl. Li, STUDIES ON THE STEREOSELECTIVE AND ENANTIOSELECTIVE SYNTHESIS OF 11,12-EPOXYSARCOPHYTOL-A, 11,12-EPOXYSARCOPHYTOL-A-ACETATE AND 11,12-EPOXYCEMBRENE-C - SYNTHESIS OF OXY-14-BROMO-2(Z),4(E),8(E)-TETRADECATRIENENITRILE, Bulletin des Societes chimiques belges, 104(8), 1995, pp. 509-513
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Bulletin des Societes chimiques belges → ACNP
ISSN journal
00379646
Volume
104
Issue
8
Year of publication
1995
Pages
509 - 513
Database
ISI
SICI code
0037-9646(1995)104:8<509:SOTSAE>2.0.ZU;2-#
Abstract
An efficient synthesis of 5,9,13-trimethyl-2-isopropyl-12(S), 13(S)-ep oxy-14-bromo-2(Z), 4(E), 8(E)-tetradecatrienenitrile, a key intermedia te in the synthesis of antitumor cembranoids including 11,12-epoxy-sar cophytol-A,11,12-epoxysarcophytol-A acetate and 11,12-epoxycembrene-C, was first described through seven step sequence in similar to 32% ove rall yield from E,E-farnesol.