BIOCHEMICAL-ALTERATIONS IN PAROMOMYCIN-TREATED LEISHMANIA-DONOVANI PROMASTIGOTES

Authors
MAAROUF M LAWRENCE F BROWN S ROBERTGERO M
Citation
M. Maarouf et al., BIOCHEMICAL-ALTERATIONS IN PAROMOMYCIN-TREATED LEISHMANIA-DONOVANI PROMASTIGOTES, Parasitology research, 83(2), 1997, pp. 198-202
Citations number
19
Categorie Soggetti
Parasitiology
Journal title
Parasitology research → ACNP
ISSN journal
09320113
Volume
83
Issue
2
Year of publication
1997
Pages
198 - 202
Database
ISI
SICI code
0932-0113(1997)83:2<198:BIPLP>2.0.ZU;2-M
Abstract
Paromomycin is used for the treatment of leishmaniasis in humans, but little is known about its mechanism of action. Investigating the effec t of this antibiotic on promastigotes of Leishmania donovani, we showe d that inhibition of the multiplication of these parasites could be re lated to its effect on RNA synthesis and to modifications of membranou s polar lipids and membrane fluidity, leading to altered membrane perm eability.