DELAYED ELEVATION OF PLATELET-ACTIVATING-FACTOR IN ISCHEMIC HIPPOCAMPUS

Authors
PETTIGREW LC MEYER JJ CRADDOCK SD BUTLER SM TAI HH YOKEL RA
Citation
Lc. Pettigrew et al., DELAYED ELEVATION OF PLATELET-ACTIVATING-FACTOR IN ISCHEMIC HIPPOCAMPUS, Brain research, 691(1-2), 1995, pp. 243-247
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
691
Issue
1-2
Year of publication
1995
Pages
243 - 247
Database
ISI
SICI code
0006-8993(1995)691:1-2<243:DEOPII>2.0.ZU;2-K
Abstract
We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) i nto the extracellular space of ischemic hippocampus. The thromboxane l evel peaked after 20 min of postischemic reperfusion, followed by a de layed PAF response 120 min later. We conclude that cerebral ischemia c auses delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.