C. Pierardfranchimont et al., SKIN WATER-HOLDING CAPACITY AND TRANSDERMAL ESTROGEN THERAPY FOR MENOPAUSE - A PILOT-STUDY, Maturitas, 22(2), 1995, pp. 151-154
Citations number
14
Categorie Soggetti
Geiatric & Gerontology","Obsetric & Gynecology","Medicine, General & Internal
The effects of menopause and hormone replacement therapy (HRT) on the
epidermis are largely unknown. The aim of this study was to model and
measure the influence of estrogen-transdermal HRT on subtle physiologi
cal changes taking place in the epidermis during the perimenopause. Sk
in capacitance and transepidermal water loss were measured both on nor
mal-looking skin and at the site of a plastic occlusion stress test (P
OST). Two groups of 15 menopausal women were enrolled. One group was u
ntreated and the other received transdermal estrogen. The water-holdin
g capacity of the stratum corneum was significantly increased at the P
OST site in women receiving transdermal estrogen. The improvement in t
he skin water-holding capacity, which is known to be associated with a
beneficial effect on the skin barrier function, may contribute to the
prevention of several dermatoses.