REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGONUCLEOTIDES BY A C=C DOUBLE-BOND - COMPARISON OF THE CIS AND TRANS ISOMERS

Authors
WENDEBORN S WOLF RM DEMESMAEKER A
Citation
S. Wendeborn et al., REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGONUCLEOTIDES BY A C=C DOUBLE-BOND - COMPARISON OF THE CIS AND TRANS ISOMERS, Tetrahedron letters, 36(38), 1995, pp. 6879-6882
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
38
Year of publication
1995
Pages
6879 - 6882
Database
ISI
SICI code
0040-4039(1995)36:38<6879:ROTPLI>2.0.ZU;2-8
Abstract
The two olefinic backbone replacements III and IV were synthesized and incorporated into oligonucleotides. The hybridization properties of t he modified oligonucleotides to DNA and RNA complements and conformati onal analyses of III and TV are compared to the corresponding amide mo difications I and II.