STUDY OF THE RESOLUTION OF AMINO-ACIDS AND AMINOALCOHOLS IN ORGANIC-SOLVENTS

The enzymatic resolution of racemic phenylglycine, phenylglycinol and phenylalaninol has been studied in organic solvents under a variety of experimental conditions. Subtilisin in 3-methyl-3-pentanol was effect ive for the resolution of phenylglycine esters, via N-acylation with t rifluoroethyl butyrate. Porcine pancreatic lipase in ethyl acetate gav e satisfactory results in the resolution of phenylglycinol and phenyla laninol; the alpha or beta position of the phenyl group was found to i nfluence both the rate and the chemioselectivity of the reaction.