CARTILAGINOUS TUMORS - PROGNOSTIC APPLICATIONS OF CYTOPHOTOMETRIC DNAANALYSIS

Background. Traditionally, selection of cancer therapy is based on the assessment of the prognosis of the individual patient. The specific t ype of tumor and the stage of disease have been the most reliable indi cators of prognosis. Methods. Image cytometry to determine DNA content was used in conjunction with clinicopathologic parameters and patient survival to investigate 16 cartilaginous tumors. Histopathologic char acteristics, cytometric DNA ploidy status, 2c deviation index (2cDI), DNA malignancy grade (DNA-MG), and Sc-exceeding event (5cEE) were used to learn more about the determination of tumor prognosis. Prognosis w as analyzed with a maximum follow-up of 148 months. Results. DNA ploid y status, 2cDI, DNA-MG, and 5cEE are indicators of prognosis. After 14 8 months of followup, patients with aneuploid tumors had a significant ly lower overall survival rate compared with those with diploid tumors (P < 0.05). Patients with DNA-MG less than 0.8 or 2cDI less than 1.5 had a significantly longer overall survival rate with respect to the g roup of patients with a DNA-MG greater than 0.8 or 2cDI greater than 1 .5 (P < 0.001). A significant difference was noted in the overall surv ival rates between patients with tumors with 5cEE less than 3 and 5cEE 3 or greater (P < 0.001). Conclusion. Image cytophotometry DNA ploidy status, 2c deviations index, DNA malignancy grade, and 5c exceeding e vent were investigated and were found to be of prognostic value for pa tients with cartilaginous tumors.