Background. Advance directives are associated with considerable contro
versy. The goal of this study was to evaluate the outcomes of critical
ly ill patients with cancer who were admitted to the intensive care un
it and who previously had executed an advance directive. The problems
associated with interpreting and honoring such documents in a tertiary
cancer center also were reviewed. Methods. A prospective observationa
l study of patients with cancer with advance directives who were admit
ted to the intensive care unit of a major cancer hospital was undertak
en. Twenty-six patients with directives were followed from the time of
admission to the intensive care unit or, in the case of patients who
presented their directives after admission, from the time of presentat
ion of the directive until either discharge or death. Results. Twenty
four of the 26 patients were placed on mechanical ventilators. Eight p
atients died while on the ventilator, nine were terminally weaned, and
seven were weaned and survived for at least 24 hours. Of these seven
patients, six died before being discharged from the hospital and one w
as discharged home. Delay in presenting the advance directive, conflic
t between the dictates of the living will and the wishes of the person
named in the durable power of attorney, and controversy among health-
care providers as to when in the course of disease the spirit of the a
dvance directive had been met were the most frequent problems encounte
red; a number of other concerns were also identified. Conclusions. Con
siderable controversy exists regarding advance directives, and such do
cuments often leave room for confusion about patients' desires in part
icular clinical situations. Many of the problems identified in this st
udy might be avoided and considerable cost savings achieved by the tim
ely presentation of documents and by the evaluation of clinical goals
on an ongoing basis.