Zanzibar is composed of two neighbouring islands with about a 1.1 mill
ion inhabitants in 2600 square kilometers, Both islands are located of
f the northeastern coast of the Tanzanian mainland, Zanzibar is a typi
cal malaria endemic area. About a third of all blood samples currently
examined for malaria in Zanzibar are positive to Plasmodium falciparu
m. Previous attempts failed to significantly improve the malaria situa
tion in Zanzibar due to administrative problems, antimalarial drug and
DDT resistance. We visited Zanzibar in order to evaluate the magnitud
e of the malaria problem and the medical logistics. This paper reviews
the results of the visit, past and present attempts to eliminate mala
ria and our conclusions regarding Zanzibar as a model site for attempt
s to eradicate malaria.