ATRIAL-NATRIURETIC-FACTOR ENHANCES NOREPINEPHRINE UPTAKE IN CIRCUMVENTRICULAR ORGANS, LOCUS-COERULEUS AND NUCLEUS-TRACTUS-SOLITARII OF THE RAT

Authors
VATTA M RODRIGUEZFERMEPIN M BIANCIOTTI L PERAZZO J MONSERRAT A FERNANDEZ B
Citation
M. Vatta et al., ATRIAL-NATRIURETIC-FACTOR ENHANCES NOREPINEPHRINE UPTAKE IN CIRCUMVENTRICULAR ORGANS, LOCUS-COERULEUS AND NUCLEUS-TRACTUS-SOLITARII OF THE RAT, Neuroscience letters, 197(1), 1995, pp. 29-32
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
197
Issue
1
Year of publication
1995
Pages
29 - 32
Database
ISI
SICI code
0304-3940(1995)197:1<29:AENUIC>2.0.ZU;2-L
Abstract
The effects of atrial natriuretic factor (ANF) on norepinephrine (NE) uptake in circumventricular organs (organum vasculosum lamina terminal is, organum subfornicale and area postrema), locus coeruleus and nucle us tractus solitarii were studied in the rat. Experiments were carried out in vitro using nuclei obtained according to the punch-out techniq ue. Results showed that 100 nM ANF enhanced NE uptake in all nuclei st udied. These results suggest that ANF may be indirectly related to the control of cardiocirculatory functions, hydroelectrolyte balance, neu roendocrine secretions, nutrient and metabolic homeostasis, through th e modulation of noradrenergic neurotransmission at the neuronal presyn aptic level.