SYNTHESIS AND BIOCHEMICAL-PROPERTIES OF P HOSPHONYL ACYCLIC ANALOGS OF 2'-DEOXYADENOSINE NUCLEOTIDES

9-[2-(phosphonomethylcarbonylamino)ethyl]adenine, 9-[(2-phosphonoethyl )aminocarbonylmethyl]adenine, {2-[(2-phosphonoethyl)carbonylamino]ethy l}adenine, and their diphosphates were synthesized. All three diphosph ates were shown to incorporate into the 3'-terminus of the DNA chain d uring the synthesis of the avian myeloblastose virus catalyzed by reve rse transcriptase. However, they do not serve as substrates for DNA po lymerase beta from human placenta, polymerase beta from calf thymus, o r terminal deoxynucleotidyl transferase from calf thymus.