UP-REGULATION OF RESISTANCE-RELATED PROTEINS IN HUMAN LUNG-TUMORS WITH POOR VASCULARIZATION

Authors
KOOMAGI R MATTERN J VOLM M
Citation
R. Koomagi et al., UP-REGULATION OF RESISTANCE-RELATED PROTEINS IN HUMAN LUNG-TUMORS WITH POOR VASCULARIZATION, Carcinogenesis, 16(9), 1995, pp. 2129-2133
Citations number
27
Categorie Soggetti
Oncology
Journal title
Carcinogenesis → ACNP
ISSN journal
01433334
Volume
16
Issue
9
Year of publication
1995
Pages
2129 - 2133
Database
ISI
SICI code
0143-3334(1995)16:9<2129:UORPIH>2.0.ZU;2-5
Abstract
Microvessel density was investigated by immunostaining endothelial cel ls for factor VIII antigen in 84 non-small cell lung carcinomas and co mpared with the expression of several resistance-related proteins. Glu tathione S-transferase-pi thymidylate synthase, metallothionein and, w ith limitations, P-glycoprotein were overexpressed in tumors with poor vascularization.