FORMATION OF A MUTAGEN, GLYOXAL, FROM DNA TREATED WITH OXYGEN-FREE RADICALS

Authors
MURATAKAMIYA N KAMIYA H IWAMOTO N KASAI H
Citation
N. Muratakamiya et al., FORMATION OF A MUTAGEN, GLYOXAL, FROM DNA TREATED WITH OXYGEN-FREE RADICALS, Carcinogenesis, 16(9), 1995, pp. 2251-2253
Citations number
20
Categorie Soggetti
Oncology
Journal title
Carcinogenesis → ACNP
ISSN journal
01433334
Volume
16
Issue
9
Year of publication
1995
Pages
2251 - 2253
Database
ISI
SICI code
0143-3334(1995)16:9<2251:FOAMGF>2.0.ZU;2-F
Abstract
Oxygen free radicals cause extensive chemical changes in DNA, includin g base and sugar modifications and strand breaks, In the present study we found that a mutagen, glyoxal, is produced by exposure of DNA to a n oxygen radical forming system (5 mM FeSO4-EDTA, 37 degrees C, 60 min ), It was produced with 17 times higher efficiency than 8-hydroxydeoxy guanosine. Thus it is possible that the formation of glyoxal is one of the major types of damage in DNA exposed to oxygen free radicals.