Word reading, hand skill on a peg-moving task and hand preference were
measured in 203 children aged from 11-13 years. Differences in skill
between the hands were largely attributable to variations in left-hand
skill, consistent with the view that manual and cerebral asymmetry ar
e due to the loss (pruning) of cells in the right hemisphere during de
velopment-a mechanism that may be dependent on the 'right shift' (rs+)
gene postulated by Annett (1985). There was only weak evidence for th
e curvilinear relation between differential hand skill and reading pre
dicted by Annett's (1985) theory of balanced polymorphism, which postu
lates a heterozygotic advantage. Reading was better predicted by absol
ute measures of hand skill than by the difference between the hands, e
specially among boys. For the boys, word reading was predicted signifi
cantly from right-hand skill, while for girls left-hand skill predicte
d slightly more strongly than right-hand skill. This may be related to
differential growth gradients in the two hemispheres, and different e
nvironmental influences for boys and girls during a period of right he
mispheric growth.