POLYCHLORINATED-BIPHENYLS (PCBS) DEPRESS ALLOGENEIC NATURAL CYTOTOXICITY BY EARTHWORM CELOMOCYTES

Authors
SUZUKI MM COOPER EL EYAMBE GS GOVEN AJ FITZPATRICK LC VENABLES BJ
Citation
Mm. Suzuki et al., POLYCHLORINATED-BIPHENYLS (PCBS) DEPRESS ALLOGENEIC NATURAL CYTOTOXICITY BY EARTHWORM CELOMOCYTES, Environmental toxicology and chemistry, 14(10), 1995, pp. 1697-1700
Citations number
25
Categorie Soggetti
Toxicology,"Environmental Sciences",Chemistry
Journal title
Environmental toxicology and chemistry → ACNP
ISSN journal
07307268
Volume
14
Issue
10
Year of publication
1995
Pages
1697 - 1700
Database
ISI
SICI code
0730-7268(1995)14:10<1697:P(DANC>2.0.ZU;2-M
Abstract
Coelomocytes of the earthworm Lumbricus terretris caused significant s pontaneous allogeneic cytotoxicity in a 24-h trypan blue assay, but no t in an assay using lactate dehydrogenase (LDH) release. Allogeneic cy totoxicity assays using cells from worms exposed to polychlorinated bi phenyls (PCBs) suggest that PCBs can suppress a natural killing (NK-li ke) reaction. The implications of this work are twofold: understanding the evolution of natural killing (NK-like) activity and providing pre liminary information on how spontaneous killing, a component of cellul ar immunity, may be compromised by pollutants.