IN-VITRO ACTIVITY OF TRIMETHOPRIM IN ASSOCIATION WITH SULFIMIDAZOLE AGAINST AEROBIC GRAM-NEGATIVE AND GRAM-POSITIVE MICROORGANISMS AND CLOSTRIDIA

The in vitro activity of a chemotherapeutic agent, sulfimidazole (SIZ) , obtained by combining two molecules belonging to groups of extremely different antibacterial drugs, p-aminobenzene sulfonamide and a deriv ative with a 5-nitroimidazole ring, was studied. In association with t rimethoprim, SIZ induces an intense synergistic antibacterial effect o n gramnegative and gram-positive aerobic microorganisms and Clostridia . The results show that, in SIZ, the activity of each starting molecul e remains unchanged providing that its structureaction relationship is kept intact.