IN-VITRO VASORELAXANT EFFECTS OF INDOLOCARBAZOLE AND BIS-INDOLE PROTEIN-KINASE-C INHIBITORS ON RABBIT RENAL-ARTERIES

Authors
FABRE S PRUDHOMME M
Citation
S. Fabre et M. Prudhomme, IN-VITRO VASORELAXANT EFFECTS OF INDOLOCARBAZOLE AND BIS-INDOLE PROTEIN-KINASE-C INHIBITORS ON RABBIT RENAL-ARTERIES, Archives internationales de pharmacodynamie et de therapie, 329(3), 1995, pp. 397-404
Citations number
26
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archives internationales de pharmacodynamie et de therapie → ACNP
ISSN journal
00039780
Volume
329
Issue
3
Year of publication
1995
Pages
397 - 404
Database
ISI
SICI code
0003-9780(1995)329:3<397:IVEOIA>2.0.ZU;2-C
Abstract
The effects of 12 compounds, structurally related to the indolocarbazo le bacterial metabolite staurosporine, on caffeine-induced contraction s in rabbit renal arteries were studied. Eight of these compounds are effective protein kinase C inhibitors, the others are inactive towards the enzyme. The results show a link between the protein kinase C inhi bitory activity and the inhibition of vascular smooth muscle contracti on, However, a strong inhibition of protein kinase C is required to ob serve the vasorelaxant effect.